Publications

2024 – Present 2016 – 2021 2005 – 2015 Book Chapters

2024

47. GHSR Deletion in β-Cells of Male Mice: Ineffective in Obesity, but Effective in Protecting against Streptozotocin-Induced β-Cell Injury in Aging

Han, H.W., Pradhan, G., Villarreal, D., Kim, D.M., Jain, A., Gaharwar, A., Tian, Y., Guo, S., Sun, Y.

Nutrients (2024)

46. AngioMT: A MATLAB based 2D image-to-physics tool to predict oxygen transport in vascularized microphysiological systems

Mathur, T., Tronolone, J. J., & Jain, A.

PLoS ONE (2024)

45. Angiogenesis-Enabled Human Ovarian Tumor Microenvironment-Chip Evaluates Pathophysiology of Platelets in Microcirculation

Ghosh, L.D., Mathur, T., Tronolone, J.J., Chuong, A., Rangel, K., Corvigno, S., Sood, K.A., Jain, A.

Advanced Healthcare Materials (2024)

44. Engineering Lymphangiogenesis-On-Chip: The Independent and Cooperative Regulation by Biochemical Factors, Gradients, and Interstitial Fluid Flow

Tronolone, J. J., Mohamed, N. & Jain, A.

Advanced Biology (2024)

2023

43. The prospects of microphysiological systems in modeling platelet pathophysiology in cancer

Ghosh, L.D. & Jain, A.

Platelets (2023)

42. Machine learning chained neural network analysis of oxygen transport amplifies the physiological relevance of vascularized microphysiological systems

Tronolone, J. J., Mathur, T., Chaftari, C. P., Sun, Y. & Jain, A.

Bioengineering & Translational Medicine (2023)

41. Electrically stimulated gene expression under exogenously applied electric fields

Abasi, S., Jain, A., Cooke, J. P., Guiseppi-Elie, A.

Frontiers in Molecular Biosciences (2023)

40. Evaluation of the Morphological and Biological Functions of Vascularized Microphysiological Systems with Supervised Machine Learning

Tronolone, J. J., Mathur, T., Chaftari, C. P., & Jain, A.

Annals of Biomedical Engineering (2023)

2022

39. Engineered models of the lymphatic vascular system: Past, Present, and Future

Selahi, A. & Jain, A.

Microcirculation (2022)

38. Vascular Transcriptomics: A Protocol for Investigating Endothelial Activation and Vascular Dysfunction Through Blood Outgrowth Endothelial Cells, Organ-Chips and RNA Sequencing.

Mathur, T., Kumar, A, Flanagan, J. M., & Jain, A.

Current Protocols (2022)

37. Intracellular calcium dynamics of lymphatic endothelial and muscle cells co-cultured in a Lymphangion-Chip under pulsatile flow

Selahi, A., Chakraborty, S., Muthuchamy, M., Zawieja, D. C., Jain, A.

Analyst (2022)

36. Cancer treatment-induced NAD⁺ depletion in premature senescence and late cardiovascular complications

Banerjee, P., Olmsted-Davis, E. A., Deswal, A., Nguyen, M.Th., Koutroumpakis, E., Palaskas, N.L., Lin, S.H., Kolta, S., Reyes-Gibby, C., Yeung, SC.J., Yusuf, S.W., Yoshimoto-Kobayashi, M., Kobayashi, M., Yu, B., Schadler, K., Herrmann, J., Cooke, J.P., Jain, A., Chini, E., Le, N.T., Abe, J.I.,

J. Cardiovasc Ageing (2022)

35. In silico analyses of blood flow and oxygen transport in human micro-veins and valves

Pandian, N. K. R., & Jain, A.

Clin Hemorheol Microcirc (2022)

34. 2D Nanosilicate for additive manufacturing: Rheological modifier, sacrificial ink and support bath, Bioprinting

S. Rajput, K.A. Deo, T. Mathur, G. Lokhande, K.A. Singh, Y. Sun, D.L. Alge, A. Jain, T.R. Sarkar, A.K. Gaharwar

Bioprinting (2022)

33. Lymphangion-chip: a microphysiological system which supports co-culture and bidirectional signaling of lymphatic endothelial and muscle cells

Selahi, A., Fernando, T., Chakraborty, S., Muthuchamy, M., Zawieja, D. C., Jain, A.

Lab on a Chip (2022)

2016 – 21

32. Acute and Chronic Cardiovascular Manifestations of COVID-19: Role for Endotheliopathy

Cooke, J.P., Connor, J.H., Jain, A.

Methodist DeBakey Cardiovasc J. (2021)

31. Comparative Analysis of Blood‐Derived Endothelial Cells for Designing Next‐Generation Personalized Organ‐on‐Chips

Mathur, T., Tronolone, J. J., & Jain, A.

Journal of the American Heart Association (2021)

30. Generalizing hydrogel microparticles into a new class of bioinks for extrusion bioprinting

Xin, S., Deo, K. A., Dai, J., Pandian, N. K. R., Chimene, D., Moebius, R. M., Jain, A., Han, A., Gaharwar, A. K., Alge, D. L.

Science Advances (2021)

29. Self-Oscillating 3D Printed Hydrogel Shapes

Nava-Medina, I. B., Gold, K. A., Cooper, S. M., Robinson, K., Jain, A., Cheng, Z. D., Gaharwar, A. K.

Advanced Material Technologies (2021)

28. 3D Bioprinted Multicellular Vascular Models

Gold, K. A., Saha, B., Pandian, N. K. R., Walther, B. K., Palma, J. A., Jo, J., Cooke, J. P., Jain, A.*, & Gaharwar, A. K.*

Advanced Healthcare Materials (2021)

27. Human tumor microenvironment chip evaluates the consequences of platelet extravasation and combinatorial antitumor-antiplatelet therapy in ovarian cancer.

Saha, B., Mathur, T., Tronolone, J. J., Chokshi, M., Lokhande, G. K., Selahi, A., Gaharwar, A. K., Afshar-Khargan, V., Sood, A. K., Bao, G., & Jain, A.

Science Advances (2021)

26. Mechanotransduction-on-chip: vessel-chip model of endothelial YAP mechanobiology reveals matrix stiffness impedes shear response

Walther, B. K., Pandian, N. K. R., Gold, K., Kiliç, E. S., Sama, V., Gu, J., Gaharwar, A. K., Guiseppi-Elie, A., Cooke, J. P., & Jain, A.

Lab on a Chip (2021)

25. Engineering New Microvascular Networks On-Chip: Ingredients, Assembly, and Best Practices

Tronolone, J. J., & Jain, A.

Advanced Functional Materials (2021)

24. Tripartite collaboration of blood-derived endothelial cells, next generation RNA sequencing and bioengineered vessel-chip may distinguish vasculopathy and thrombosis amongst sickle cell disease patients.

Mathur, T., Flanagan, J. M., & Jain, A.

Bioengineering & Translational Medicine (2021)

23. Microengineered Human Vein‐Chip Recreates Venous Valve Architecture and Its Contribution to Thrombosis

Pandian, N. K. R., Walther, B. K., Suresh, R., Cooke, J. P., & Jain, A.

Small (2020)

22. Thromboresistance of Polyurethanes Modified with PEO-Silane Amphiphiles.

Ngo, B. K. D., Lim, K. K., Johnson, J. C., Jain, A., & Grunlan, M.

Macromolecular Bioscience (2020)

21. OvCa-Chip microsystem recreates vascular endothelium–mediated platelet extravasation in ovarian cancer

Saha, B., Mathur, T., Handley, K. F., Hu, W., Afshar-Kharghan, V., Sood, A. K., & Jain, A.

Blood Advances (2020)

20. Thromboresistance of Silicones Modified with PEO-Silane Amphiphiles

Ngo, B. K. D., Barry, M. E., Lim, K. K., Johnson, J. C., Luna, D. J., Pandian, N. K. R., Jain, A., & Grunlan, M.

ACS Biomaterials Science & Engineering (2020)

19. Tortuosity-powered microfluidic device for assessment of thrombosis and antithrombotic therapy in whole blood

Luna, D. J., Pandian, N. K. R., Mathur, T., Gadangi, P., Kostousov, V. V., Hui, S.-K. R., Teruya, J., & Jain, A.

Nature Scientific Reports (2020)

18. Organ-on-chips made of blood: endothelial progenitor cells from blood reconstitute vascular thromboinflammation in vessel-chips

Mathur, T., Singh, K. A., Pandian N.K.R., Tsai, S. H., Hein, T. W., Gaharwar, A. K., Flanagan, J. M., & Jain, A.

Lab on a Chip (2019)

17. Emerging trends in multiscale modeling of vascular pathophysiology: Organ-on-a-chip and 3D printing

Gold, K., Gaharwar, A. K., & Jain, A.

Biomaterials (2019)

16. Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models

Papa, A. L., Jiang, A., Korin, N., Chen, M. B., Langan, E. T., Waterhouse, A., Nash, E., Caroff, J., Graveline, A., Vernet, A., Mammoto, A., Mammoto, T., Jain, A., Kamm, R. D., Gounis, M. J., & Ingber, D. E.

Science Translational Medicine (2019)

15. Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems

Barrile, R., van der Meer, A. D., Park, H., Fraser, J. P., Simic, D., Teng, F., Conegliano,D., Nguyen J., Jain, A., Zhou, M., Karalis, K., Ingber, D. E., Hamilton, G. A., Otieno, M. A.

Clinical Pharmacology & Therapeutics (2018)

14. PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury

De Ceunynck K., Peters C. G., Jain A., Higgins S. J., Aisiku O., Fitch-Tewfik J. L., Dockendorff C., Parikh S. M., Ingber D. E., & Flaumenhaft R.

PNAS (2018)

13. Thrombosis-on-a-chip: Prospective impact of microphysiological models of vascular thrombosis

Pandian, N. K. R., Mannino, R. G., Lam, W. A., & Jain, A.

Current Opinion in Biomedical Engineering (2018)

12. Engineering “Endothelialized” Microfluidics for Investigating Vascular and Hematologic Processes Using Non-Traditional Fabrication Techniques

Mannino, R. G., Pandian, N. K. R., Jain, A., Lam, W. A.

Current Opinion in Biomedical Engineering (2018)

11. A primary human lung alveolus‐on‐a‐chip model of intravascular thrombosis for assessment of therapeutics

Jain, A.*, Barrile, R.*, van der Meer, A. D., Deceunynck, K., Mammoto, A., Mammoto, T., Aisiku, O., Otieno, M. A., Louden, C. S., Hamilton, G. A., Flaumenhaft, R., & Ingber, D. E.

Clinical Pharmacology & Therpaeutics (2018)

10. Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium

Jain, A.*, van der Meer, A. D.*, Papa, A. L., Barrile, R., Lai, A., Schlechter, B. L., Otieno, M. A., Louden, C. S., Hamilton, G. A., Michelson, A. D., Frelinger, A. L., & Ingber, D. E.

Biomedical Microdevices (2016)

9. A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function

Jain, A., Graveline, A., Waterhouse, A., Vernet, A., Flaumenhaft, R., & Ingber, D. E.

Nature Communications (2016)

2005 – 2015

Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K. J., Karalis, K., Kim, H. J., MacQueen, L., Mahmoodian, R., Musah, S., Torisawa, Y. S., van der Meer, A. D., Villenave, R., Yadid, M., Parker, K. K., & Ingber, D. E. Engineered in vitro disease models. Annu Rev Pathol. 2015;10:195-262.
doi: 10.1146/annurev-pathol-012414-040418.
Leslie, D. C., Waterhouse, A., Berthet, J. B., Valentin, T. M., Watters, A. L., Jain, A., Kim, P., Hatton, B. D., Nedder, A., Donovan, K., Super, E. H., Howell, C., Johnson, C. P., Vu, T. L., Bolgen, D. E., Rifai, S., Hansen, A. R., Aizenberg, M., Super, M., Aizenberg, J., & Ingber, D. E. A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling. Nat Biotechnol. 2014 Nov;32(11):1134-40.
doi: 10.1038/nbt.3020.
Cooper, R. M., Leslie, D. C., Domansky, K., Jain, A., Yung, C., Cho, M., Workman, S., Super, M., & Ingber, D. E. A microdevice for rapid optical detection of magnetically captured rare blood pathogens. Lab Chip. 2014 Jan 7;14(1):182-8.
doi: 10.1039/c3lc50935d.
Jain, A., & Munn, L. L. Biomimetic postcapillary expansions for enhancing rare blood cell separation on a microfluidic chip. Lab Chip. 2011 Sep 7;11(17):2941-7.
doi: 10.1039/c1lc20401g.
Jain, A., & Munn, L. L. Determinants of leukocyte margination in rectangular microchannels. PLoS One. 2009 Sep 21;4(9):e7104.
doi: 10.1371/journal.pone.0007104.
Jain, A., & Posner, J.D. Particle dispersion and separation resolution of pinched flow fractionation. Anal Chem. 2008 Mar 1;80(5):1641-8.
doi: 10.1021/ac0713813.
Jain, A., Choudhary, S., Singh, S. N., & Rai, L. Flow characteristics of model can combustor: Effect of casing angle. Journal of the Institution of Engineers (India): Mechanical Engineering Division. 2006 Apr;87:1-7.
Link.
Jain, A., Choudhary, S., Rai, L., & Singh, S. N. Flow analysis in a model can-type gas turbine combustor. Indian Journal of Engineering & Materials Sciences. 2005 Oct;12:389-97.
Link.

Book Chapters

Jain, A., Mathur, T., Pandian, N. K. R., & Selahi, A. Organ-on-a-chip and 3D printing as preclinical models for medical research and practice. In Precision Medicine for Investigators, Practitioners and Providers (pp. 83-95). Academic Press.
doi: 10.1016/C2018-0-03029-7.
Munn, L. L., & Jain, A. Lab on a chip technologies and applications. Design and fabrication of microfluidic devices for flow-based separation of blood cells. Rasooly, A., editor. UK: Horizon Scientific Press; 2008.
Link.