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The Bioinspired Translational Microsystems Laboratory

BioinSyst

Texas A&M University College of Engineering

Gallery

Gallery


https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/06/Selahi.Analyst.2022.Movie_1.mp4

Analyst, 2022.

3D confocal micrograph of a quarter of the lumen formed of a confluent monolayer of LECs (green) surrounded by multiple layers of LMCs (red) embedded in 3D ECM made using GLP technique.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/06/Selahi.Analyst.2022.Movie_2.mp4

Analyst, 2022.

Timelapse fluorescent video of LECs intracellular calcium content (Fluo-4) while the Lymphangion-Chip lumen was exposed to step shear profile.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/06/Selahi.Analyst.2022.Movie_3.mp4

Analyst, 2022.

Timelapse fluorescent video of LMCs intracellular calcium content (Fluo-4) while the Lymphangion-Chip lumen was exposed to step shear profile.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Mathur.BioenggTranslMed.2021.Movie_1.mp4

Bioengineering & Translational Medicine, 2021.

Time series showing platelet adhesion on BOEC-vessel-chips for control and patients SCD1 and SCD2. Each frame is 4 min apart but for presentation, the movie runs at 0.5 frames per second.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Pandian.Small_.2020.Movie_3.mp4

Small, 2020.

Endothelialized Vein-Chip. A confluent lumen formed by HUVECs in the four walls of a Vein-Chip (green – VE-cadherin, blue – nucleus).

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Pandian.Small_.2020.Movie_1.mp4

Small, 2020.

Perfusion of blood through Vein-Chip: Five-minute time-lapse video of the perfusion of the human whole blood through plasma-treated Vein-Chip (snap every 15 seconds).

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Pandian.Small_.2020.Movie_2.mp4

Small, 2020.

Endothelialization of Vein-Chip: 18-hour time-lapse video of the endothelial lumen formation using HUVECs in a Vein-Chip (snap every 15 minutes).

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Pandian.Small_.2020.Movie_4.mp4

Small, 2020.

Blood perfusion through healthy Vein-Chip: 15-minute time lapse video of recalcified whole blood perfused through an endothelialized (HUVECs) Vein-Chip (snap every 1 minute).

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Pandian.Small_.2020.Movie_5.mp4

Small, 2020.

Blood perfusion through TNF-alpha treated Vein-Chip: 15-minute time lapse video of recalcified whole blood perfused through TNF-α (5 ng/ml) treated endothelialized (HUVECs) Vein-Chip (snap every 1 minute).

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Pandian.Small_.2020.Movie_6.mp4

Small, 2020.

Confocal image of thrombus formed in Vein-Chip: Confocal image of a thrombus formed at the cusp of a TNF-α (5 ng/ml) treated endothelialized Vein-Chip (fibrin (magenta), platelets (green)).

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Pandian.Small_.2020.Movie_7.mp4

Small, 2020.

Perfusion of heparin treated blood through Vein-Chip: 15-minute timelapse video of heparin treated recalcified whole blood perfused through TNF-α (5 ng/ml) treated endothelialized (HUVECs) Vein-Chip (snap every 1 minute).

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Saha.BloodAdv.2020.Movie_1.mp4

Blood Advances, 2020.

Time lapse video showing platelet extravasation (CD41 stained, red) from vascular compartment into the tumor compartment. The focal plane is within the cancer cell compartment of the OvCa-Chip.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Saha.BloodAdv.2020.Movie_2.mp4

Blood Advances, 2020.

3D rotation of confocal scans of OvCa-Chip at different times showing degradation of vascular junctions relative to Control-Chip (green, VE Cadherin; blue, ovarian cancer cell).

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Saha.BloodAdv.2020.Movie_3.mp4

Blood Advances, 2020.

3D rotation of confocal scans of vessels formed inside OvCa-Chip, showing an intact lumen in Control-Chip, endothelial barrier loss in OvCa-Chip and, subsequent restoration of endothelial barriers of OvCa-Chip treated with 10 nM atorvastatin.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Luna.NatSciRep.2020.Movie_1.mp4

Nature Scientific Reports, 2020.

Brightfield video of whole blood flow in the microchannels of the tortuosity activated device.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Mathur.LabChip.2019.Movie_2.mp4

Lab on a Chip, 2019.

A 3D reconstruction of confocal micrographs of the vessel on-chip lined with BOECs on all sides of the channel and stained for VE-cadherin and nuclei.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Mathur.LabChip.2019.Movie_1.mp4

Lab on a Chip, 2019.

(Left) Timelapse images of endothelial cells dividing and proliferating within vessel-chips kept inside a cell culture incubator. (Right) Quantification of total microchip area covered by the endothelial cells. The vessel-chip becomes confluent with endothelial lumen within 48 hours of cell seeding.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Mathur.LabChip.2019.Movie_3.mp4

Lab on a Chip, 2019.

Time series showing platelet adhesion on BOEC-vessel-chips with or without TNF-α treatment. Each frame is 5 minutes apart but for presentation, the movie runs at two frames per second.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Jain.ClinicalPharma.2018.Movie-1-1.mp4

Clinical Pharmacology & Therapeutics, 2018.

3D confocal reconstruction of the lung alveolus-on-chip showing epithelial junctions (yellow) and endothelial junctions (green).

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Jain.ClinicalPharma.2018.Movie-2-1.mp4

Clinical Pharmacology & Therapeutics, 2018.

Platelet coverage (red) upon whole blood perfusion on collagen coated lower microchannel of the lung alveoli-on-a-chip containing no endothelium. Magnification ×10; frame rate: six frames per minute; total runtime: 12 min.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Jain.ClinicalPharma.2018.Movie-1.mp4

Clinical Pharmacology & Therapeutics, 2018.

Platelet coverage (red) upon whole blood perfusion on lower microchannel of the lung alveolus-chip containing healthy endothelium lined over collagen. Magnification ×10; frame rate: six frames per minute; total runtime: 12 min.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Jain.ClinicalPharma.2018.Movie-2.mp4

Clinical Pharmacology & Therapeutics, 2018.

Platelet coverage (red) upon whole blood perfusion on lower microchannel of the lung alveolus-on-chip containing endothelium treated with tumor necrosis factor-α (TNF-α). Magnification ×10; frame rate: six frames per minute; total runtime: 12 min.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Jain.ClinicalPharma.2018.Movie-3.mp4

Clinical Pharmacology & Therapeutics, 2018.

Platelet coverage on a laser-injured mouse blood vessel in vivo. Magnification ×20; frame rate: five frames per second; total runtime: 4 min.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Jain.ClinicalPharma.2018.Movie-4.mp4

Clinical Pharmacology & Therapeutics, 2018.

Whole blood flow (recalcified citrated blood) in the lung alveolus- chip containing an intact primary human alveolar epithelium overlying an untreated endothelium (not shown). Magnification ×10; frame rate: two frames per minute; total runtime: 20 min.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Jain.NatComm.2016.Movie-1.mp4

Nature Communications, 2016.

Time-lapse imaging of fluorescent fibrinogen in whole blood containing 0.75 IU ml-1 heparin anticoagulant and an applied flow rate corresponding to shear rate gradient of 4,375 sec-1mm-1.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Jain.BiomedMicrodev.2016.Movie-1.mp4

Biomedical Microdevices, 2016.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Jain.BiomedMicrodev.2016.Movie-2.mp4

Biomedical Microdevices, 2016.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Jain.LabChip.2011.mp4

Lab on a Chip, 2016.

The operation of an optimal nucleated-cell (NC) separation device.

 

https://jain.engr.tamu.edu/wp-content/uploads/sites/187/2022/04/Jain.PlosOne.2009.mp4

Plos One, 2016.

Video showing Fluorescent WBCs marginated to the sidewalls of a 50 µm wide microchannel (20×magnification). The RBC hematocrit was 20%.

 

Department of Biomedical Engineering
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College Station, TX, 77843

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